منابع مشابه
Modelling Solvent-mediated Polymorphic Transitions during Cooling Solution Crystallization
Polymorphism is one of the most important issues raised by the industrial crystallization of Active Pharmaceutical Ingredients (API). The dynamic modelling of polymorphic transformations is developed using Femlab, a multiphysics simulation software, which is applied to the resolution of the Populations Balance Equations (PBE) involved. The stable and metastable distinct populations of crystals ...
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In recent years, significant effort has been devoted to the development of drug formulation with the purpose of targeting and controlled release. The micro/nanosizing of drugs has been identified as a potentially effective and broadly applicable approach. In the pharmaceutical industry several conventional techniques have been utilized for particle size reduction. The disadvantages of these tec...
متن کاملPredicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures.
In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acet...
متن کاملAnti-TRAP protein from Bacillus subtilis: crystallization and internal symmetry.
Anti-TRAP protein regulates the expression of tryptophan biosynthetic genes by binding to TRAP and preventing formation of the TRAP-RNA complex. Anti-TRAP from Bacillus subtilis has been crystallized by vapour diffusion. The crystals belong to space group P1, with unit-cell parameters a = 51.6, b = 60.1, c = 60.4 A, alpha = 114.0, beta = 101.4, gamma = 100.5 degrees. X-ray data have been collec...
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The possibility of preparation of hydrogenated phosphatidylcholine (HPC) liposome precursors (LP) using supercritical anti-solvent technology (SAS) was evaluated. Vitamin D (VD) and coenzyme Q10 (CoQ10) were chosen as the model drugs, and HPC was used as the wall material. The influences of operation conditions (pressures, concentrations and etc.) on the HPC were studied. The structure of the L...
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ژورنال
عنوان ژورنال: Crystals
سال: 2020
ISSN: 2073-4352
DOI: 10.3390/cryst10090748